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1. Tai, T.W. The role of drainage after total knee arthroplasty / T.W. Tai, C.Y. Yang, C.W .

Chang // Recent Advances in Hip and Knee Arthroplasty. 2007. P. 267274 .

2. Mardian, S. Wound drainage in Primary knee arthroplasty a prospective randomized study / S. Mardian, C. Perka, G. Matziolis // Acta chirurgiae orthopaedicae et traumatologiae cechpslovaca. 2013. Vol. 80, 2. P. 114117 .

3. Esler, C.N. The use of a closed sunction drain in total knee arthroplasty / C.N. Esler, C .

Blakeway, N.J. Fiddian // The journal of bone and joint surgery. British volume. 2003. Vol. 85, 2 .

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4. Sharma, G. M. Use of a close suction drain after primary total knee arthroplasty an overrated practice / G.M. Sharma, G. Palekar, D.D. Tanna // Sicot-J. 2016. Vol. 39, 2. P. 14 .

   

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2. Larsen, S.H. Sexual function and obesity / S.H. Larsen, G. Wagner, B.L. Heitmann // Int. J. Obes. 2007. Vol. 8. . 118998 .

3. Health issue of men: prevalence and correlates of erectile dysfunction / R. Shabsigh [et al.] // J .

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4. Esposito, K. Obesity, the metabolic syndrome, and sexual dysfunction / K. Esposito, D. Giugliano // Int. J. Impot. Res. 2005. Vol. 17, 5. . 391398 .

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Speel, H. van Langen, E.J. Meuleman // Eur. Urol. 2003. Vol. 44. . 366370 .

11. Matfin, G. Erectile dysfunction: interrelationshipwith the metabolic syndrome / G. Matfin, A. Jawa, V.A. Fonesca // Curr. Diab. Rep. 2005. Vol. 5. . 6469 .

12. The Dark Side of Testosterone Review Deficiency: I. Metabolic Syndrome and Erectile Dysfunction / A.M. Traish [et al.] // J. Androl. 2009. Vol. 30. P. 1022 .

   

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, , , .

.

1. .

2. 2-3 .

3. 4-6, .

:

1. / . .. . . :

, 2006. 187 .

2. . / . . .,1997 .

3. / . .. . . : , 2001. 660 .

-

   

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:

1. : . /. . [ .] ; . . . . . : . ., 2007. 703 .

2. / . .. , .. . , 2012. 509 .

   

. () , . , , , 5-20% . [1]. , . [2] .

. , , ; , .

. 96 2015-2016 , ϻ .

. 96 .

70 (72,9 %), 26 (21,7%) (. 1) .

2. 71-80 -29% 81 -21%. 60 .

(. 3): , 97,9%, -72,9%, - 52,1%, - 31,3%, .

, . 4 .

.

:

, 2,7 , .

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.

:

1. , . . / . . . . : -., 2000. 288 .

2. , . . , / . . // . . 2008. . 13, 3. . 15-19 .

   

. (). - [1]. . - [2, 3]. [4] .

. - . .

. 397 , 3 2011-2015 .

, , .

, . 77 96 (80,20%), 45 77 (58,44%), 30 77 (38,96%), 2 77 (2,60%). 19 96 (19,80%) .

:

Enterococcusfaecalis, Klebsiellapneumoniae, Pseudomonaseruginosa, Staphylococcusepidermidis, Staphylococcusureus, Proteusmirabilis. . , (+ ) . . 3 , .

. 1 .

   

.

1. .

2. .

:

1. , . . / . . . : , 2000. 627 .

2. , . . : / . .

, .. . : . 304 .

3. / .. [ .] // . . 2007. 3. . 410 .

4. / . . JI.C .

, .. , .. . : , 2007. 464 .

CA19-9

.., .., .., .., . .

. () , . , , , , . , , , , , , .

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. () [1, 2]. 28% , [1, 3, 4]. . [2]. -, [2-5]. : , ; , , . .

, ( ) .

. .

. 160 ( 82, 58), 2012 2016 . . 52,4 12,2 (̱). CEA : 2 47 , 3 23, 4b 48, , 5 17, 6 25. , , , . , , . , , . .

:

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. 50% . . : ( , II III ), ; , , .

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, , , , (0,05). 6 (0,05). : , 2, 1, 1 .

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.

1. .

2. .

:

1. : . / .. [ .]. ., 2011. 94 .

2. / .. [ .] // . .-. . . . .. . 2016. 1. . 75-85 .

3. , .. / .. . . : , 2013 .

336 .

4. Plebology / A.A. Ramelet [et al.]. Elsevier Masson SAS-All rights reserved, 2008. 570 .

5. / .. [ .]. :

, 2015. . 51-70 .

   

. , - (1). , G .

Guarnera et al., , (2). , , - (3) .

. () .

. 45 , : 12 33 . 23 , 6 - , 11 - , , 5 ( 5 ). , D- - . 31 , 33 , 22 - .

, .

. 47,6% , mixt- - 33,3%, 19,1%) . D- ( 0,6 ) 34,8% . , 6 (76,7%), . D- 2 , . D- , - 6,6% .

D- ( 0,3 ) , 6 . ( 39,1% ), 3 . , , {3- ( 60%), , . , , .

( 25%) ( 16,7%) D- .

. , D- . , , D- |3 .

:

1. Simka, . Cellular and molecular mechanisms of venous leg ulcers development - the "puzzle" theory / . Simka // Intl Angiol. 2010 Feb. Vol. 29, N 1. P. 1-19 .

2. Pharmacological and surgical management of venous ulcers / G. Guarnera [et al.] // Acta Vulnologica. 2010 Dec. Vol. 8, N4 .

3. Geronemus, R.G. Wound healing. The effects of topical antimicrobial agents / R.G. Geronemus, P.M. Mertz, W.H. Eaglstein // Arch. Dermatol. 1979. Vol. 115. P. 131114 .

   

. () 15 30 % 90% ( .., 2004; .. ., 2006; .. ., 2007; .., .., 2008). , , , [1] .

. (), (, ) , ( .. ., 1996; Gehrmann G. et al., 2008) .

, 60 (Young B., Rayan G., 2000; Pechlaner S., 2002). : 30%, 10% ( .. ., 1999; .. ., 2003; Anzarut . et al., 2004) .

. ( ) [2] .

, , , - . . 1200 - , 500 - , 1500 - . , (fossa scaph- oidea, fossa lunata, fossa articulatio radioulnaris distalis), 25 (- ) - 10-15 .

2 , ( - ) .

, , , ( .. ., 2004; .. ., 2006; .. ., 2007) .

. .

. ϻ . 2009 2014 .. . , . () (-) .

. ϻ . 2009 2014 . . 6754 .

89,5% , 72,9% . 4 . , 2238 (33,1%), .

, . , 2150 (96,1%) , 4 6 . .

(Cooney, Krimmer H., 2001).: , , .

, . 20 . 21 50 .

2 1 3 . I , (230 ). II , (210 ) .

. , 40 (21,1%) , 190 (78,9%). 180 (85,8%) . 30 (14,2%) .

.

1. , , .

2. 7 .

3. 85,8% .

:

1. , .. . :

. - . / .. , .. , .. . . : , 2003. 57 .

2. , .. / .. // . . 2010. 4. C. 8489 .

   

. () , [1]. [2], , , , [3] .

.

. - , 82 2011. 60 34 78 . 57(69,5%), - 25 (30,5%) .

NM (7- 2009 ) 1N0M0 3, 1N1M0 - 1, 2N0M0 - 11, 2 N1M0 - 3, 3N0M0 - 27, 3N1M0 - 29, 4N0M0 - 1 4N1M0 7 , .. I 14, II- - 60 III- 8. 73 ,

4 , 3 - 2 .

10, - 44, - 19, 4 5 .

. Statistica (v.10.0) . 2011-2015 400 , 82 (20,5%) . () 73, 2, 4 . 9, - 2 . 5 - (1), (3), (1) .

2016 , , 22 (26,8%). 3- 12(54,5%) , 1 1, 1 -4, 2- 2, 3- -2 4 -3 . I 14 6 (42,9%), II 60 16 (26,7%) 8 III- . (N1) 40 4 (10%), , . ( ) 10 (45,5%) 3 27 , (7 10) 1 . 6 . 10 6 4 .

82 60(73,2%), 30 - 6 (10 %), 2-6 - 16 (26,7%), 7-12 23 (38,3%), 1 2 7 (11,7%) 2 3 - 8 (13,3%) . , (45 60 75,0%) . 238 ( I- 360, II- 223 III- 166 ). II- III- 234 .

( 5-) 25 82 (30,5%). 5 , , , , 5-, .

, , 255 , 241 , .. .

. 397 , - 550 , , - 382 , , 296 . , , , .

.

1. .

2. , , , .

:

1. International Cancer of the Pancreas Screening (CAPS) Consortium summit on the management of patients with increased risk for familiar pancreatic cancer / M.I. Canto [et al.] // Gut. 2013. Vol. 62, 3. P. 339-347 .

2. / .. [ .] // . . 2012. . 6, 1(21). .45-59 .

3. / .. [ .] // . . 2004. . 5, 2. . 115-125 .

-

   

. , , . , , [1]. , , [2, 3]. , , , [4]. , . , , .

. .

. 30 , 2013 2015 .

: . . , . 15 (9 (60%) 6 (40%)) (13 (86,67%)) (2 (13,33%)). -- . 54,263,72 , 87,2620,92 2 ( 20 2 320 2). 15 (8 (53,33%) 7 (46,67%)) (12 (80%)) (3 (20%)). - . 56,863,87 , 72,0616,18 2 ( 21 2 220 2). , , , , (0,05) .

, ( , - , ); , , , , . .. (1942) .. . (2008). - . (, , , , 10% , 3% ) (, -) (, , ) .

. Statistica .

- ( - ( 20150024 19.01.2015.) USP 2 metric 5 40 , . 1,5 , 1,5 , . 15 - 4 . , (15 ) (3,5 ) . . , . .

.

1-2 - 1 .

   

, 1,66 , ( 0,93 ), ( 1,2 ), 1,8 .

. - , .

:

1. , .. / .. , .. , .. .

, 2012. 496 .

2. Primary closure of cutaneous abscesses: a systematic review / A.J. Singer [et al.] // Am. J .

Emerg. Med. 2011 May. Vol. 29, N 4. P. 361-66. doi: 10.1016/j.ajem.2009.10.004 .

3. , .. / . .

, .. // . . . . . . 2010. . 15, 3. . 59-67 .

4. / .. [ .] // . 2014. . 12, 2. . 7-12 .

ͨ

   

. , 20 60%, " " 45-92,8% [1]. 80% [4]. . . 42-68% [2]. , 60 , 10-15 .. [3]. .

: .

132 , . 87, 52,67,4 , 45, 63,58,7 . 73,3%, 26,7% 23,3% , 37,5% . , , , , , , .

39,2% , 51%, 9,8%. , 30,3% 2 (12,9%) 12 (0,8%) .

.

. , , . , , . 24-48 . , , 23. , . . .. . .. , . 12 , 52,2% .

3 19 17 . 88,2%. . (58,8%) . 9, 52,9% .

, , . . 2-8 . , , , , . .

31 . 20 ( 10 ). 11 ( 7 ). St. aureus E.coli. seudomonas aeruginosa, andida spp., lebsiella pneumoniae. - E. Coli andidaspp, E. Coli Klebsiellaoxytoca, E. Coli Pseudonadaaeruginosa. , 75% .

: , . , .

:

1., .. / .. , .. // . . .. . 2014. . 173, 1. . 089-092 .

2. , / . .

[ .] // IX . . . , , 1819 2016 . / . .. . . 201-203 .

3. / .. [ .] // . 2005. 5. . 38-42 .

4., .. / .. , .. , .. // . . . .

-. 2009. 2 (26). . 280-281 .

   

. . [1]. , . 3- .

. 35% [2,3]. (15%), 20-40% [4,5,6] .

.

. 9 , 2015 2016 . 7 2 . , 68 91 . 86,6 . 2 , 7 4-5 .

. : 4 (44,4%) , - 2 (22,2%), 1 (11,1%), 3 (33,3%), 1 (11,1%), - 1 (11,1%), 2 (22,2%), 1 (11,1%), 2 (22,2%), - 3 (33,3%), 1 (11,1%). , .

, . : , , , , , , , , . ( ). ( ) .

. 87- : , , . : . , : , , , , , , .

. 76 : , , , , - , : III , IV IV , , , , . : , . , , 4 . .

- .

- .

. . .

, , . , .

, , .

:

1. / .. [ .] // . . 2008. 3. . 248 .

2. / .. [ .]. . : , 2000. 144 .

3. , .. / .. , . .

. . : . ., 2006. . 115-118 .

4. , .. / .. , .. // . 2001. 9. . 30-31 .

5. , .. 50 / .. . . : -, 2006 .

6. , .. / .. , .. , .. // . 2005. 1. . 20-23 .

:

   

. , . , , -, , .

20 , , - .

.

, . , , , .

. 2- - 3- . , : - , , , , . , , .

. 67 ( 2,5 8 ), . 24- , ( ; ); 12- (, ); 31 , ( ). 1-2 .

, .

. , , : 1. ( ) 2. , , ( ) .

, , , - (-), , , .. .

., , , . , ( ), - . [1] .

, , , , .

. , , .. , . , . - , ( ) , . , . - , , , , , . : , , .

, ( ) , , . ( ) . , , . , , . , , , , , , .

. - , , .

:

1. , . : . . / . . . : , 2000. 608 .

.

   

. 0,1 0,4 % [1,3]. . , [2,3] .

.

, , , , , , [2,3,4]. 20% [2,3] .

, , , , [2,3,4] .

, , , 60 100% [1,2,3,4]. , .

. . .

. 359 2005-2014 , .

. 359 , 10 , 229 (63,8%) 130 (36,2 %) 35 92 . 30 (8,4%) , (76,6 %), 71 .

, 10 , . 2005 2009 153 (42,6%), 2010 2012 169 (47,1%) .

2013 2014 37 (10,3%) .

204 , 56,8%, 155 (43,2%). , 2013 2014 , .

, , , , . , .

, 85 (23,7%) , (274 , 67,9%). 2 (2013 2014 ) 32 (62, 2%) .

31 , 8,6% . 115 , 32%. 129 (35,9%). , 244 (57,9%) , .

, , , .

321 , 89,4%. 38 (10,6%) . . 321 (89,4%) 38 (10,6%) . 50 (15,6%), 52 , 16,2%. (18,7%). , .

90 (28%), 35 (10,9%). (10,6%). , 50% .

. , , , 70 (76,6%) .

10 56,8 %, .

, , 89,4% .

:

1. , .. : / .. , .. . /, 2005. 378 .

2. , .. : . . . / .. . ., 2014. 99 .

3. / .. [ .] // . . 2011. 5 . 37 .

4. , .. . . :

, 1997. 208 .

   

. , , () [1]. (). . , [2]. C-erb2/Her2-neu (IAP) (BIRC5) [3] .

, , C-erb2/Her2-neu (IAP) (BIRC5) .

. 45 . 5 2, is-4N0-1M0. . real-time PCR Cerb2/Her2-neu BIRC5. c-BL. c-BL .

. 29 , 64,4%, 45 . , 23 (51,1%), , -ABL 6 (13,3%) .

BIRC5 15 (33,3%). C-erb2/Her2-neu 21 (46,6%) .

13 (28,8%) .

- (Mm) 1,20130,193965 (min 0,0017; max 10,7083) .

- (Mm) 1,68860,0939 (min 0,1032; max 17,4401) .

, , .

. . , , , , - . 0 TNM .

.

:

1. Gupta, G.P. Cancer metastasis: building a framework / G.P., Gupta, J. Massagu // Cell. 2006. Vol. 127, N 4. P. 67995 .

2. Pantel, K. Cancer micrometastases / K. Pantel, C. Alix-Panabires Riethdorf // Nat Rev Clin Oncol. 2009. Vol. 6, N 6. P. 33951 .

3. The prognostic role of circulating tumor cells (CTCs) detected by RT-PCR in breast cancer: a meta-analysis of published literature / S. Zhao Liu Y [et al.] // Breast Cancer Res Treat. 2011. Vol. 130. P. 809816 .

   

() . 1 200 000

- 300 000 [1, 2, 3] .

: .

. ., 21 . , . . : . , . , . , . , , 6 : 1 , 2 . 1: , ; , ; , ; 2: , , , , , ; , , . , : .

. ( , , ) , , 17q12-21 12q11-13, 1 10 . , . ( ) . , . .

. : , , , , . , . . . , , zoom, [1] .

, , , , , , , . , (Curth Macklin), [2, 3] .

- . , , . ( ) , . , . , , , . , , . . . .

, . , , [2, 3] .

. , , .

:

1. . LVI. / .. [ .] // . 2012. . 11, 4. . 324328 .

2. Epidermolytic Hyperkeratosis: a case report / Marcos Takeyoshi Hayashida [et al.] // An Bras Dermatol. 2015. Vol. 90, 6. P. 888-891 .

3. An appraisal of acitretin therapy in children with inherited disorders of keratinization / M.Lacour [et al.] // Br. J. Dermatol. 1996. Vol. 134, 6. . 102329 .

   

.., .., .., . .

. () , , . , [1, 2]. , 50-80% [3, 4]. , 29% 45% [5]. , . , , Clostridium difficile .

, .

() 2015-2016 . .

2015 2122 , 59,1% . - 2016 1690 , 78% .

, 2015 16,8% , . (24,6%), 5,4% .

. , , , , . 3,9% (5,6% , 1,4% - ). 8,1-14,4% , - , . 11,4-13,9% , , . (39,8%), (10,4%) , 14,9-16% : 20,6%- , 11,1% - . (1,5-1,7%), , .

, Clostridium difficile, 2% , 90% . 2 2016 .

. . , . , , , .

, , , (, ) (). .

:

1. , .. : / .. , .. , .. . : , 2006. 106 .

2. , / .. [ .] // . 2004. 4. . 85-91 .

3. Glass, R.I. Beyond discovering the viral agents of acute gastroenteritis / R.I. Glass // Emerg Infect Dis. 2013. Vol. 19, 8. P. 1190-1191 .

4. / .. [ .] // . . 2012. 1. . 13-15 .

5. Rotavirus and severe childhood diarrhea / U.D. Parashar [et al.] // Emerg. Infect. Dis. 2006. Vol. 12, 2. P. 304-306 .

-

   

. - , , , . , , . - - . 60 , , , - [1] .

- , 86-100% . - . - [2] .

- .

. 54 2014 . , , . 32 (59%) 22 (41%) . 34,9 (95% : 30,839,0, min 16, max 73). 14 (95% : 12,615,4, min 8, max 28) .

- 2 : 8-10 . - . () 2 , .

. - 58,6 (95% : 56,560,7, min 39,0, max 73,5), 60,8 (95% : 58,962,7, min 44,2, max 75,7). . 1 .

   

-30....-20 1 1,9

-20....-10 8 14,8 -30....0 23 42,6

-10....0 14 25,9 0....10 19 35,2 10....20 10 18,5 0....30 31 57,4 20....30 2 3,7 61% , - ( , ) 10%. 22% 10%-27%, 17% 10%-24% .

. - , . - , .

:

1. Abeylath, S.C. Drug delivery approaches to overcome bacterial resistance to beta-lactam antibiotics / S.C. Abeylath, E. Turos // Expert. Opin. Drug. Deliv. 2008. Vol. 5, 9. P. 931-949 .

2. - / .. [ .] // : . : . . 368-370 .

   

. . , , [1,2,3,4]. , , . - : , , - , [3,4,5] .

. .

. 12 , , , ( ) 5, ( ) 4, 1, 1 . : 4 , 1 (); 1 1 . .

. 2%- . .

. . , (=1) (=1) , . 2- , , .

, , . - .

, , - . , . - . . .

. . . .

, . , , , , , . . . , . . .

.

1. , , .

2. .

3. .

:

1. , .. / .. . : , 1972. 267 .

2. (, , ) / .. [ .] ; . .

.. . . : , 1982. 236 .

3. , .. ( , , ) : / .. . : , 2007. 227 .

4. , .. / .. , .. . . : , 2006. 752 .

5. : 2 . / . . .. , .. . . : , 1993. . 1 : . . 336 .

D-

   

. , , . 20-30%, . . , , . , [1, 2, 3] .

. D- [4] () () .



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